ARVC can be caused by changes in genes that encode for proteins that are involved in the structure and function of the heart muscle. ARVC is inherited in an autosomal dominant manner.
ARVC can be caused by variants in genes that encode for proteins that are involved in the structure and function of the heart muscle. These proteins include desmosomal proteins, which are involved in cell-to-cell adhesion in the heart muscle.
Mutations in the PKP2 gene are the most common cause of familial ARVC. Other genes that have been linked to ARVC include DSG2, DSP, and JUP.
Genetic testing is not always necessary for diagnosing ARVC. The condition can also be diagnosed based on clinical symptoms, such as arrhythmias or abnormal electrocardiogram (ECG) results.
Some cases may be due to other factors, such as viral infections or inflammation.